More bad news about COVID vaccines: Immune Tolerance

Highly technical but important new medical thinking

Here is a term that is probably new to most people, but it is very important:

Immune tolerance (Immunological tolerance) represents a state of unresponsiveness of the immune system to substances or tissues that would otherwise have the capacity to trigger an immune response in a given organism.  

A disturbing premise based on some research, could repeated exposure to the mRNA COVID-19 vaccines be leading to more illness? While the mainstream will undoubtedly ignore this yet to be peer reviewed work, science does need to pursue implications of the mass vaccination response to COVID-19, including inquiries into this topic.

A group of scientists affiliated with University of South Florida, King Abdulaziz University (Saudi Arabia), Cross Cancer Institute (Canada) and the University of Guadalajara in Mexico recently uploaded to the preprint server a provocative hypothesis for further investigation concerning COVID-19 vaccination. Acknowledging that the COVID-19 vaccines have helped prevent hospitalization and more severe forms of the disease, with 69.7% of the total population now immunized by these products, the authors suggest that mounting research points to the real possibility that the mRNA vaccine may induce immune tolerance, along with that caused by SARS-CoV-2 itself could potentially complicate the clinical course of COVID-19 infection.

What are some details?

The eclectic team of investigators point to recent research indicating high IgG4 levels in persons who have received two or more mRNA vaccine doses. But what’s the significance of heightened IgG4 levels? 

According to these authors, at least some experts posit that greater IgG4 levels represent a protective role by “preventing immune over-activation, similar to that occurring during successful allergen-specific immunotherapy by inhibiting IgE-induced effects.”

What’s the hypothesis?

Pointing to emerging evidence, the authors report that greater IgG4 levels measured after repeated exposure to mRNA vaccines “is not a protective mechanism; rather, it may be part of the immune tolerance mechanisms to the spike protein that could promote unopposed SARS-CoV-2 infection and replication by suppressing natural antiviral responses.”

Frightening reality if true

While this recent study is not peer reviewed (and thus shouldn’t be cited as medical evidence), the output does have a basis for further investigation, based on cited examples in this study.  With 13.32 billion COVID-19 vaccine doses of diverse platforms administered to date, the total number of fully mRNA vaccinated individuals in America alone equals well over 200 million people. In the USA, 613 million doses in total have been administered.

What is the hypothesis that repeated exposure to mRNA COVID-19 vaccines is leading to immune tolerance? Could this be at least one explanation for why Omicron has become so virulent? What about the excess death rates covered by this and other independent media, yet not touched by the mainstream press? What about the hypothesis that IgG4-induced suppression of the immune system associated with multiple mRNA doses could lead to higher incidence of autoimmune diseases while also potentially promoting cancer growth or even autoimmune myocarditis in susceptible persons?

While this recent paper hasn’t been peer reviewed nor will it likely get much mainstream exposure, for that very reason this media suggests other scientists review the evidence and the arguments carefully.

Here is the technical medical paper: “IgG4 Antibodies Induced by mRNA Vaccines Generate Immune Tolerance to SARS-CoV-2’spike Protein by Suppressing the Immune System.”

“Abstract

Due to the health crisis caused by SARS-CoV-2, the creation of a new vaccine platform based on mRNA was implemented. Globally, around 13.32 billion COVID-19 vaccine doses of diverse platforms have been given, and up to this date, 69.7% of the total population received at least one injection of a COVID-19 vaccine. Although these vaccines prevent hospitalization and severe forms of the disease, increasing evidence has shown they do not produce sterilizing immunity, allowing people to suffer frequent re-infections. Recent research has also raised concerns that mRNA vaccines could induce immune tolerance, which, added to that caused by the virus itself, could complicate the clinical course of a COVID-19 infection. Furthermore, recent investigations have found high IgG4 levels in people who were administered two or more injections of mRNA vaccines. It has been suggested that an increase in IgG4 levels could have a protecting role by preventing immune over-activation, similar to that occurring during successful allergen-specific immunotherapy by inhibiting IgE-induced effects. Altogether, evidence suggests that the reported increase in the IgG4 levels detected after repeated vaccination with the mRNA vaccines is not a protective mechanism; rather, it may be a part of the immune tolerance mechanism to the spike protein that could promote unopposed SARS-CoV2 infection and replication by suppressing natural antiviral responses. IgG4-induced suppression of the immune system due to repeated vaccination can also cause autoimmune diseases, promotes cancer growth, and autoimmune myocarditis in susceptible individuals.”

“Finally, these negative outcomes are not expected to affect all people who have re-
ceived these mRNA vaccines. Individuals with genetic susceptibility, immune deficien-cies, and co-morbidities probably would be the most likely to be affected. However, this gives rise to a disturbing paradox: if people who are the most affected by the COVID-19 disease (the elderly, diabetics, hypertensive, and immunocompromised people like those with HIV) are also more susceptible to suffering the negative effects of mRNA vaccines, is it then justified to booster them? As Omicron subvariants have been demonstrated to be less pathogenic, and mRNA vaccines do not protect against re-infection, clinicians should be aware of the possible detrimental effects on the immune system by administering boosters.”

Source