Vitamin D is essential for the human body to fight SARS-COV-2 [Laderoute M, Trained immunity involving HERV-K102 activation my promote recovery from COVID-19 providing a new vaccination paradigm against pandemic RNA viruses ( submitted) ]. There are two types of foamy macrophages the lipid body negative, highly vacuolated MI like proinflammatory macrophages (LB-FMs) which produce the HERV-K102 particles and the lipid body positive (oil red o strongly positive)M2 like anti-inflammatory macrophages (LB+FMs). Many viruses and other intracellular pathogens [Dias SSG et al, PLoS Pathogens, 2020; Wu X et al., Microbiol Pathog 2021; Cho HJ et al , BMC Infect Dis 2020] infect the protector LB-FM and convert them to the LB+FM to knock out the HERV-K102 protector system. Vitamin D deficiency promotes this conversion favoring the invading viruses and pathogens which is exacerbated with diabetes [Oh J et al, Circulation 2009]. Only the LB-FMs and its immediate precursors exhibit a highly active VDR signalling pathway of the 66 different cell types identified in BALF from severe patients [Ren X et al., Cell, 2021]. Yes, vitamin D is vital to survival!
Vitamin D, adopted as a non-toxic alternative to problematic Covid19 (C19) injections. clearly qualifies as a superior "toxics-use reduction" option. It is everywhere as widely available and cost free as the summer sun. In terms of rich dietary sources, Vitamin D can be produced as inexpensively and easily as homemade mushroom tea.
I would be surprised if anything like the 0.125 mg vitamin D required for proper immune system function for 70 kg 154 lb bodyweight could be obtained, per day, via any palatable or practical amount of mushroom tea. My other comment links to references on the need for such intakes. This is only a gram every 22 years, and pharma grade vitamin D3 cholecalciferol costs USD$2.50 a gram ex-factory. I take a 1.25 mg 50,000 IU capsule once a week. This is 7143 IU a day, and the cost is both minimal and a lot less than taking 7 or so 1000 IU capsules, which are the largest allowed on retail shelves, here in Australia.
New scare tactics aside i.e. 'new variant'!! There is NO such thing as immunity from these shots, non whatsoever!!! From what I've seen of effects & illness of friends and family, those who've had 3 shots have fallen ill, some very ill from the 3rd shot & some have had several bouts of COVID, which have been worse each time. No I'm not a doctor, but I don't think it takes a doctor to come to a conclusion that these shots are a. NOT vaccines (stop infection & spread) & b. provide ANY immunity. Vitamin D, C, Zinc & quercitin are great to boost your immune system, especially if you've had these shots!!!
We've known since April 2020 that people taking plaquenil had almost no cases of COVID.
I advise 5000Iu/d of vitamin-D, except for those well over 200# and/or without a gallbladder, then 10,000IU/d. Checking levels is good. I take the dose i advise and my last 2 levels, years apart were 78 and 83. drjohnsblog.substack.com
Regarding 50 ng/mL 125 nmol/L circulating 25-hydroxyvitamin D, as needed for proper immune system function, how most unsupplemented people have 1/10 to 1/2 of this, how for 70 kg 154 lb body-weight, 0.125 5000 IU vitamin D3 a day is needed (for several months) to attain this and how to boost the level safely over 50 ng/mL in 4 hours with a single oral dose of calcifediol (which is 25-hydroxyvitamin D), please see Prof. Sunil Wimalawansa's recent article: https://www.mdpi.com/2072-6643/14/14/2997, the research articles cited at:https://vitamindstopscovid.info/00-evi/ .
This extensive literature review of single high-dose vitamin-D treatment and results indicates that one-time dosing of 200,000 to 300,000 IU is appropriate, which is what I began to advise at diagnosis of cOVID in those not supplementing already.
Thanks for this link to Kearns et al. 2014, which I had not seen before.
Han et al. 2016 "High dose vitamin D administration in ventilated intensive care unit patients: A pilot double blind randomized controlled trial " https://www.sciencedirect.com/science/article/pii/S2214623716300084 used, over 5 days, 500,000 IU vitamin D3 with ICU patients who were - or who were expected to be - mechanically ventilated. This reduced average time in hospital from 36 to 18 days. 250,000 IU over 4 days reduced the average hospital stay to 25 days. These arrangements would have taken at least 4 days and probably a week to attain the desired 25-hydroxyvitmin D levels
For medical emergencies, a single oral dose of 0.014 mg per kg bodyweight will attain this in 4 hours - and so is obviously a superior approach.
Hard to imagine how hospitals in 2020 hit by ill COVID patients could ignore this 2016 paper with very impressive data on benefits of high dose vitamin D treatment; I am confident that the pandemic could have been stopped and many lives saved if this treatment had been used.
Vitamin D is essential for the human body to fight SARS-COV-2 [Laderoute M, Trained immunity involving HERV-K102 activation my promote recovery from COVID-19 providing a new vaccination paradigm against pandemic RNA viruses ( submitted) ]. There are two types of foamy macrophages the lipid body negative, highly vacuolated MI like proinflammatory macrophages (LB-FMs) which produce the HERV-K102 particles and the lipid body positive (oil red o strongly positive)M2 like anti-inflammatory macrophages (LB+FMs). Many viruses and other intracellular pathogens [Dias SSG et al, PLoS Pathogens, 2020; Wu X et al., Microbiol Pathog 2021; Cho HJ et al , BMC Infect Dis 2020] infect the protector LB-FM and convert them to the LB+FM to knock out the HERV-K102 protector system. Vitamin D deficiency promotes this conversion favoring the invading viruses and pathogens which is exacerbated with diabetes [Oh J et al, Circulation 2009]. Only the LB-FMs and its immediate precursors exhibit a highly active VDR signalling pathway of the 66 different cell types identified in BALF from severe patients [Ren X et al., Cell, 2021]. Yes, vitamin D is vital to survival!
Vitamin D, adopted as a non-toxic alternative to problematic Covid19 (C19) injections. clearly qualifies as a superior "toxics-use reduction" option. It is everywhere as widely available and cost free as the summer sun. In terms of rich dietary sources, Vitamin D can be produced as inexpensively and easily as homemade mushroom tea.
See: "Make Your Own Vitamin D Supplements for Pennies (Using Summer Sunlight and Mushrooms)". https://www.youtube.com/watch?v=YeYR1C7NMUI
Also see: "How Vitamin D Affects Every Organ and Tissue". https://www.youtube.com/watch?v=zCmW5bLcE9s
UV-irradiated mushrooms provide vitamin D2 ergocalciferol. This is inferior to the vitamin D3 cholecalciferol produced in the skin and which is used in most vitamin D supplements. See Jones et al. 2014: https://academic.oup.com/jcem/article/99/9/3373/2538621 and Hicks 2022: https://www.medscape.com/viewarticle/969165 .
I would be surprised if anything like the 0.125 mg vitamin D required for proper immune system function for 70 kg 154 lb bodyweight could be obtained, per day, via any palatable or practical amount of mushroom tea. My other comment links to references on the need for such intakes. This is only a gram every 22 years, and pharma grade vitamin D3 cholecalciferol costs USD$2.50 a gram ex-factory. I take a 1.25 mg 50,000 IU capsule once a week. This is 7143 IU a day, and the cost is both minimal and a lot less than taking 7 or so 1000 IU capsules, which are the largest allowed on retail shelves, here in Australia.
Please see this. Vitamin D3 bolus dosing of 200,000-300-000 Iu is appropriate in most cases.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4128480/
New scare tactics aside i.e. 'new variant'!! There is NO such thing as immunity from these shots, non whatsoever!!! From what I've seen of effects & illness of friends and family, those who've had 3 shots have fallen ill, some very ill from the 3rd shot & some have had several bouts of COVID, which have been worse each time. No I'm not a doctor, but I don't think it takes a doctor to come to a conclusion that these shots are a. NOT vaccines (stop infection & spread) & b. provide ANY immunity. Vitamin D, C, Zinc & quercitin are great to boost your immune system, especially if you've had these shots!!!
We've known since April 2020 that people taking plaquenil had almost no cases of COVID.
I advise 5000Iu/d of vitamin-D, except for those well over 200# and/or without a gallbladder, then 10,000IU/d. Checking levels is good. I take the dose i advise and my last 2 levels, years apart were 78 and 83. drjohnsblog.substack.com
Regarding 50 ng/mL 125 nmol/L circulating 25-hydroxyvitamin D, as needed for proper immune system function, how most unsupplemented people have 1/10 to 1/2 of this, how for 70 kg 154 lb body-weight, 0.125 5000 IU vitamin D3 a day is needed (for several months) to attain this and how to boost the level safely over 50 ng/mL in 4 hours with a single oral dose of calcifediol (which is 25-hydroxyvitamin D), please see Prof. Sunil Wimalawansa's recent article: https://www.mdpi.com/2072-6643/14/14/2997, the research articles cited at:https://vitamindstopscovid.info/00-evi/ .
Regarding calcifediol: https://vitamindstopscovid.info/04-calcifediol/ and https://nutritionmatters.substack.com/p/calcifediol-to-boost-25-hydroxyvitamin .
This extensive literature review of single high-dose vitamin-D treatment and results indicates that one-time dosing of 200,000 to 300,000 IU is appropriate, which is what I began to advise at diagnosis of cOVID in those not supplementing already.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4128480/
Thanks for this link to Kearns et al. 2014, which I had not seen before.
Han et al. 2016 "High dose vitamin D administration in ventilated intensive care unit patients: A pilot double blind randomized controlled trial " https://www.sciencedirect.com/science/article/pii/S2214623716300084 used, over 5 days, 500,000 IU vitamin D3 with ICU patients who were - or who were expected to be - mechanically ventilated. This reduced average time in hospital from 36 to 18 days. 250,000 IU over 4 days reduced the average hospital stay to 25 days. These arrangements would have taken at least 4 days and probably a week to attain the desired 25-hydroxyvitmin D levels
For medical emergencies, a single oral dose of 0.014 mg per kg bodyweight will attain this in 4 hours - and so is obviously a superior approach.
Hard to imagine how hospitals in 2020 hit by ill COVID patients could ignore this 2016 paper with very impressive data on benefits of high dose vitamin D treatment; I am confident that the pandemic could have been stopped and many lives saved if this treatment had been used.